2. PROTAC
  3. Molecular Glues
  4. JWJ-01-306

JWJ-01-306 is a molecular glue that targets the C2H2 zinc finger transcription factor ZBTB11. JWJ-01-306 degrades ZBTB11, reduces the oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. JWJ-01-306 exhibits good pharmacokinetic characteristics in mouse model.

For research use only. We do not sell to patients.

JWJ-01-306 Chemical Structure

JWJ-01-306 Chemical Structure

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Description

JWJ-01-306 is a molecular glue that targets the C2H2 zinc finger transcription factor ZBTB11. JWJ-01-306 degrades ZBTB11, reduces the oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. JWJ-01-306 exhibits good pharmacokinetic characteristics in mouse model[1].

Molecular Weight

574.98

Formula

C28H26ClF3N4O4
SMILES

FC(F)(F)C1=C(Cl)C=CC(CCNC2(CCC2)C3=CC(NC(C(N4C5CCC(NC5=O)=O)=O)=CC4=O)=CC=C3)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JWJ-01-306 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JWJ-01-306Molecular GluesPaCa-2C57BL/6 mousesotorasibpancreatic ductal adenocarcinomasInhibitorinhibitorinhibit

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