2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. JY-XHe-053

JY-XHe-053 is a potent and selective agonist of GABAA receptors containing the α5 subunit (Kis of 22.0 nM, 12.3 nM, 34.9 nM, 0.7 nM for α1, α2, α3, α5, respectively). JY-XHe-053 lacks significant anti-anxiety activity, despite its efficacy at α2- and α3-GABAA receptors.

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JY-XHe-053 Chemical Structure

JY-XHe-053 Chemical Structure

CAS No. : 612526-36-0

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JY-XHe-053 Related Antibodies

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Description

JY-XHe-053 is a potent and selective agonist of GABAA receptors containing the α5 subunit (Kis of 22.0 nM, 12.3 nM, 34.9 nM, 0.7 nM for α1, α2, α3, α5, respectively). JY-XHe-053 lacks significant anti-anxiety activity, despite its efficacy at α2- and α3-GABAA receptors[1][2].

Molecular Weight

373.38

Formula

C22H16FN3O2
CAS No.
SMILES

O=C(OCC)C1=C2CN=C(C3=CC(C#C)=CC=C3N2C=N1)C4=CC=CC=C4F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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JY-XHe-053 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JY-XHe-053612526-36-0GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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