2. PROTAC
  3. Target Protein Ligand-Linker Conjugates
  4. K-Ras ligand-Linker Conjugate 6

K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

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K-Ras ligand-Linker Conjugate 6 Chemical Structure

K-Ras ligand-Linker Conjugate 6 Chemical Structure

CAS No. : 2378261-89-1

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K-Ras ligand-Linker Conjugate 6 Related Antibodies

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Description

K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K-Ras ligand-Linker Conjugate 6 Related Antibodies
Molecular Weight

788.98

Formula

C42H60N8O7
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(N1[C@@H](CC#N)CN(C2=C3C(CN(C4=C5C=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)C[C@H](OCCOCCOCCOCCN)C6)=N2)CC1)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (63.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2675 mL 6.3373 mL 12.6746 mL
5 mM 0.2535 mL 1.2675 mL 2.5349 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2675 mL 6.3373 mL 12.6746 mL 31.6865 mL
5 mM 0.2535 mL 1.2675 mL 2.5349 mL 6.3373 mL
10 mM 0.1267 mL 0.6337 mL 1.2675 mL 3.1686 mL
15 mM 0.0845 mL 0.4225 mL 0.8450 mL 2.1124 mL
20 mM 0.0634 mL 0.3169 mL 0.6337 mL 1.5843 mL
25 mM 0.0507 mL 0.2535 mL 0.5070 mL 1.2675 mL
30 mM 0.0422 mL 0.2112 mL 0.4225 mL 1.0562 mL
40 mM 0.0317 mL 0.1584 mL 0.3169 mL 0.7922 mL
50 mM 0.0253 mL 0.1267 mL 0.2535 mL 0.6337 mL
60 mM 0.0211 mL 0.1056 mL 0.2112 mL 0.5281 mL
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K-Ras ligand-Linker Conjugate 6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras ligand-Linker Conjugate 62378261-89-1Target Protein Ligand-Linker ConjugatesK-RasE3ligasesVHLCRBNMDM2IAPproteindegradationPROTACDegrader-1Inhibitorinhibitorinhibit

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