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  3. Fluorescent Dye
  4. K114

K114, un analogue fluorescent du Congo rouge, se lie étroitement aux fibrilles amyloïdes avec un EC50 de 20-30 nM. K114 est un détecteur efficace d'activateur dérivé du sperme d'infection virale (SEVI).

K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI).

For research use only. We do not sell to patients.

K114 Chemical Structure

K114 Chemical Structure

CAS No. : 872201-12-2

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Based on 1 publication(s) in Google Scholar

K114 Related Antibodies

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Description

K114, a fluorescent Congo Red analogue, binds tightly to amyloid fibrils with an EC50 of 20-30 nM[1]. K114 is an efficient detector of semen-derived enhancer of virus infection (SEVI)[2].

In Vitro

K114's unusually low buffer fluorescence is due to self-quenching in sedimentable aggregates or micelles which upon interacting with amyloid fibrils undergo an enhancement in fluorescence intensity and shifts in the excitation and emission spectra[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

K114 Related Antibodies
Molecular Weight

393.27

Formula

C22H17BrO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

Emission (Em)

550
Excitation (Ex)

498
SMILES

BrC1=CC(/C=C/C2=CC=C(O)C=C2)=CC=C1/C=C/C3=CC=C(O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5428 mL 12.7139 mL 25.4278 mL
5 mM 0.5086 mL 2.5428 mL 5.0856 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (244 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5428 mL 12.7139 mL 25.4278 mL 63.5696 mL
5 mM 0.5086 mL 2.5428 mL 5.0856 mL 12.7139 mL
10 mM 0.2543 mL 1.2714 mL 2.5428 mL 6.3570 mL
15 mM 0.1695 mL 0.8476 mL 1.6952 mL 4.2380 mL
20 mM 0.1271 mL 0.6357 mL 1.2714 mL 3.1785 mL
25 mM 0.1017 mL 0.5086 mL 1.0171 mL 2.5428 mL
30 mM 0.0848 mL 0.4238 mL 0.8476 mL 2.1190 mL
40 mM 0.0636 mL 0.3178 mL 0.6357 mL 1.5892 mL
50 mM 0.0509 mL 0.2543 mL 0.5086 mL 1.2714 mL
60 mM 0.0424 mL 0.2119 mL 0.4238 mL 1.0595 mL
80 mM 0.0318 mL 0.1589 mL 0.3178 mL 0.7946 mL
100 mM 0.0254 mL 0.1271 mL 0.2543 mL 0.6357 mL
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K114 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K114872201-12-2K 114K-114Fluorescent DyeInhibitorinhibitorinhibit

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