KAAD-Cyclopamine  (Synonyms: Cyclopamine-KAAD)

KAAD-Cyclopamine, a hedgehog signaling inhibitor, is a smoothened antagonist^[1].

KAAD-Cyclopamine inhibits pathway activation induced by 1 μM purmorphamine with an IC₅₀ of 3 nM, wheras this cyclopamine derivative has an IC₅₀ of 100 nM in Shh-LIGHT2 cells stimulated with 10 μM purmorphamine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

697.99

C₄₄H₆₃N₃O₄

306387-90-6

Solid

White to light yellow

C[C@H]([C@@](N1CCNC(CCCCCNC(CCC2=CC=CC=C2)=O)=O)([H])[C@](C[C@H](C)C1)([H])O3)[C@@]43C(C)=C(C[C@@]5([H])[C@@]6([H])CC=C(C7)[C@@]5(CCC7=O)C)[C@@]6([H])CC4

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Surajit Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat Chem Biol. 2006 Jan;2(1):29-30.  [Content Brief]

  [2]. Xiaoli Ma, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis. 2005 Oct;26(10):1698-705.  [Content Brief]