2. Immunology/Inflammation
  3. Kallikrein
  4. Kallikrein 5-IN-2 TFA

Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC50 of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome.

For research use only. We do not sell to patients.

Kallikrein 5-IN-2 TFA Chemical Structure

Kallikrein 5-IN-2 TFA Chemical Structure

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Other Forms of Kallikrein 5-IN-2 TFA:

Kallikrein 5-IN-2 TFA Related Antibodies

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View All Kallikrein Isoform Specific Products:

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KLK1 KLK5 KLK8 KLK14 KLKB1

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Description

Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC50 of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome[1].

IC50 & Target

KLK5

7.1 (pIC50)

KLK8

6.1 (pIC50)

KLK14

5.4 (pIC50)

KLKB1

5.2 (pIC50)

KLK1

4.2 (pIC50)

Molecular Weight

512.48

Formula

C25H23F3N6O3
SMILES

N=C(C1=CC=C(NCC2=NC=C(C3=CC=CC=C3)N2)C=C1OCC4=CC=CN=C4)N.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Kallikrein 5-IN-2 TFA Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kallikrein 5-IN-2KallikreinKLKKallikrein-related peptidaseNetherton syndromeselectiveInhibitorinhibitorinhibit

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HY-148949A
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