Kazinol F

Cat. No.: HY-113732: FAQs
Data Sheet Handling Instructions

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Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Kazinol F Chemical Structure

CAS No. : 104494-35-1

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human A549 cells after 5 days by MTT assay Cytotoxicity against human A549 cells after 5 days by MTT assay	[PMID: 11575957]
HCT-8	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human HCT8 cells after 5 days by MTT assay Cytotoxicity against human HCT8 cells after 5 days by MTT assay	[PMID: 11575957]
KB	ED₅₀	> 10 μg/mL Compound: 6	Cytotoxicity against human KB cells after 5 days by MTT assay Cytotoxicity against human KB cells after 5 days by MTT assay	[PMID: 11575957]

In Vitro

Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity (-8.1kcal/mol)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

396.52

Formula

C₂₅H₃₂O₄

CAS No.

104494-35-1

SMILES

OC1=CC(CCCC2=CC=C(C=C2O)O)=C(C(C/C=C(C)\C)=C1O)C/C=C(C)\C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ghosh, Rajesh et al. Identification of polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease inhibitors using in silico docking and molecular dynamics simulation approaches. J Biomol Struct Dyn. vol. 39,17 (2021): 6747-6760. [Content Brief]

Kazinol F Related Classifications

Inflammation/Immunology Infection

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kazinol F104494-35-1SARS-CoVSARS coronavirusCOVID-19SARS CoV-2 main proteasepolyphenolBroussonetia papyriferaMproInhibitorinhibitorinhibit

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