KB-141

Cat. No.: HY-117167: FAQs
Data Sheet Handling Instructions

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KB-141 is a potent and selective TRβ agonist. The IC₅₀ values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo.

For research use only. We do not sell to patients.

KB-141 Chemical Structure

CAS No. : 219691-94-8

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Description

IC₅₀ & Target

219691-94-8

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	0.78 nM Compound: 2a	Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay Activity against TRAFbeta expressed in CHOK1 cells by alkaline phosphatse reporter gene assay	[PMID: 17543524]
CHO-K1	EC₅₀	1.7 nM Compound: 2a	Activity against TRAF-alpha-1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay Activity against TRAF-alpha-1 expressed in CHOK1 cells by alkaline phosphatase reporter gene assay	[PMID: 17543524]
CV-1	EC₅₀	1.12 nM Compound: 2, KB-141	Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells by TRE-luciferase assay Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells by TRE-luciferase assay	[PMID: 18585912]
CV-1	EC₅₀	4.5 nM Compound: 2, KB-141	Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells by TRE-luciferase assay Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells by TRE-luciferase assay	[PMID: 18585912]

Molecular Weight

355.21

Formula

C₁₇H₁₆Cl₂O₄

CAS No.

219691-94-8

SMILES

O=C(CC1=CC(Cl)=C(C(Cl)=C1)OC2=CC=C(C(C(C)C)=C2)O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

KB-141 Related Classifications

Cancer

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KB-141219691-94-8KB141KB 141Thyroid Hormone ReceptorTHRanti-obesityanti-diabeticlipid-loweringInhibitorinhibitorinhibit

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