2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. KB-141

KB-141 is a potent and selective TRβ agonist. The IC50 values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo.

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KB-141 Chemical Structure

KB-141 Chemical Structure

CAS No. : 219691-94-8

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KB-141 Related Antibodies

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Description

KB-141 is a potent and selective TRβ agonist. The IC50 values are 23.9 nM and 3.3 nM for binding affinities from displacement of T3 from hTRα1 and hTRβ1, respectively. KB-141 has anti-obesity, anti-diabetic, and lipid-lowering effects?and can be used as an anti-cholesteremic agent in vivo[1][2].

IC50 & Target

219691-94-8
Molecular Weight

355.21

Formula

C17H16Cl2O4
CAS No.
SMILES

O=C(CC1=CC(Cl)=C(C(Cl)=C1)OC2=CC=C(C(C(C)C)=C2)O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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KB-141 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KB-141219691-94-8KB141KB 141Thyroid Hormone ReceptorTHRanti-obesityanti-diabeticlipid-loweringInhibitorinhibitorinhibit

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