2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. KC 12291 hydrochloride

KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo.

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KC 12291 hydrochloride Chemical Structure

KC 12291 hydrochloride Chemical Structure

CAS No. : 181936-98-1

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KC 12291 hydrochloride Related Antibodies

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Description

KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].

In Vitro

KC 12291 hydrochloride (1 μM) reduces the peak of Na+ current approximately 60 % in rat ventricular cardiomyocytes[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KC 12291 hydrochloride Related Antibodies
In Vivo

KC 12291 hydrochloride (0.63 mg/kg for p.o; once) exerts significant antiischemic activity in anesthetized rabbit model[1].
KC 12291 hydrochloride (60 mg/kg for p.o) has plasma Cmax values of 1.3 and 1.4 μg/mL for female and male rats, respectively, and the value of plasma Tmax is close to 2 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized rabbit model[1]
Dosage: 0.16, 0.63 mg/kg
Administration: Oral administration (p.o.); Once
Result: Significantly attenuated the coronary occlusion produced marked ST segment elevation about 68 % at 0.63 mg/kg.
Molecular Weight

449.99

Formula

C22H28ClN3O3S
CAS No.
SMILES

[H]Cl.CN(CCCOC1=NSC(C2=CC=CC=C2)=N1)CCC3=CC=C(OC)C(OC)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KC 12291 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KC 12291181936-98-1KC12291KC-12291Sodium ChannelNa channelsNa+ channelsAntiischemicCardioprotectivevoltage-gated sodium channelVGSCAnesthetized rabbit model.Inhibitorinhibitorinhibit

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