KC01

Cat. No.: HY-120299 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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KC01 is an effective inhibitor of ABHD16A, with IC₅₀s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages .

For research use only. We do not sell to patients.

KC01 Chemical Structure

CAS No. : 1646795-59-6

Size	Price	Stock	Quantity
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
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Description

IC₅₀ & Target

90 nM for hABHD16A and 520 nM for mABHD16A^[1]

In Vitro

KC01 (0-20 μM, 30 min) is a potent inhibitor of ABHD16A with an IC₅₀ < 90 nM^[1].
KC01 (1 μM, 4 h) significantly reduces lyso-PSs in colon cancer cells (COL205, K562, and MCF7)^[1].
KC01 (1 μM, 4 h) reduces lyso-PS and LPS-induced cytokine production in mouse macrophages^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HEK293T
Concentration:	0 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
Incubation Time:	30 min
Result:	Showed KC01 inhbited ABHD16A in a concentration-dependent manner.

Molecular Weight

365.55

Formula

C₂₂H₃₉NO₃

CAS No.

1646795-59-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(N)CCCC/C=C1C(OC\1CCCCCCCCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (263 KB) SDS (393 KB)

COA (240 KB)

Handling Instructions (2659 KB)

References

[1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. [Content Brief]

KC01 Related Classifications

Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KC011646795-59-6KC 01KC-01OthersinflammationABHD16A inhibitionInhibitorinhibitorinhibit

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