Kdo2-Lipid A ammonium

Name: Kdo2-Lipid A ammonium
Brand: MedChemExpress
SKU: HY-N8277
Rating: 5.0 (2 reviews)

Cat. No.: HY-N8277 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2.

For research use only. We do not sell to patients.

Kdo2-Lipid A ammonium Chemical Structure

CAS No. : 1246298-62-3

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1 mg	USD 890	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Kdo2-Lipid A ammonium:

Kdo2-Lipid A Get quote

2 Publications Citing Use of MCE Kdo2-Lipid A ammonium

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•Related Small Molecules:

•Related Proteins:

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

View All TNF Receptor Isoform Specific Products:

View All Isoforms

TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TLR4

In Vitro

Kdo2-Lipid A (1 μM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	TNF and PGE2
Concentration:	1 µM
Incubation Time:
Result:	Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.

In Vivo

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats (Male Holzman Sprague-Dawley, 300–400 g) ^[1]
Dosage:	0.1 to 10 µg
Administration:	I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:	Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.

Clinical Trial

Molecular Weight

2306.84

Formula

C₁₁₀H₂₁₄N₆O₃₉P₂

CAS No.

1246298-62-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C[C@@H](CC)OC(CC)=O)O[C@@H]([C@@H]([C@H]1CO[C@](C[C@H]([C@@H]2O)O[C@@](O[C@]([C@H]3O)([H])[C@H](O)CO)(C[C@H]3O)C(O)=O)(O[C@]2([H])[C@H](O)CO)C(O)=O)O[P](O)(O)=O)[C@H]([C@@H](O1)OC[C@@H](O[C@@H]4O[P](O)(O)=O)[C@H]([C@@H]([C@H]4NC(C[C@H](O)CC)=O)OC(C[C@H](O)CC)=O)O)NC(C[C@@H](CCC)OC(CC)=O)=O.N.N.N.[10].[12].[9].[10].[10].[10].N

Structure Classification

Others

Initial Source

Microorganisms

E. coli

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

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Data Sheet (287 KB) SDS (252 KB)

COA (275 KB)

Handling Instructions (2659 KB)

References

[1]. Saito O, et al. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol. 2010;160(7):1754-1764. [Content Brief]