2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) TNF Receptor
  4. Kdo2-Lipid A ammonium

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2.

For research use only. We do not sell to patients.

Kdo2-Lipid A ammonium Chemical Structure

Kdo2-Lipid A ammonium Chemical Structure

CAS No. : 1246298-62-3

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Based on 2 publication(s) in Google Scholar

Other Forms of Kdo2-Lipid A ammonium:

Kdo2-Lipid A ammonium Related Antibodies

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2 Publications Citing Use of MCE Kdo2-Lipid A ammonium

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Description

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2[1].

IC50 & Target

TLR4

 

In Vitro

Kdo2-Lipid A (1 μM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kdo2-Lipid A ammonium Related Antibodies

RT-PCR[1]

Cell Line: TNF and PGE2
Concentration: 1 µM
Incubation Time:
Result: Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.
In Vivo

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (Male Holzman Sprague-Dawley, 300–400 g) [1]
Dosage: 0.1 to 10 µg
Administration: I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result: Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.
Clinical Trial
Molecular Weight

2306.84

Formula

C110H214N6O39P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C[C@@H](CC)OC(CC)=O)O[C@@H]([C@@H]([C@H]1CO[C@](C[C@H]([C@@H]2O)O[C@@](O[C@]([C@H]3O)([H])[C@H](O)CO)(C[C@H]3O)C(O)=O)(O[C@]2([H])[C@H](O)CO)C(O)=O)O[P](O)(O)=O)[C@H]([C@@H](O1)OC[C@@H](O[C@@H]4O[P](O)(O)=O)[C@H]([C@@H]([C@H]4NC(C[C@H](O)CC)=O)OC(C[C@H](O)CC)=O)O)NC(C[C@@H](CCC)OC(CC)=O)=O.N.N.N.[10].[12].[9].[10].[10].[10].N
Structure Classification
Initial Source

E. coli
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

COA (275 KB)

Handling Instructions (2659 KB)
References
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Kdo2-Lipid A ammonium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kdo2-Lipid A1246298-62-3Toll-like Receptor (TLR)TNF ReceptorTumor Necrosis Factor ReceptorTNFRlipopolysaccharideTLR4TNFPGE2Inhibitorinhibitorinhibit

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