Kentsin 

Kentsin, a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation. Kentsin has opiate properties on gastrointestinal motility^[1][3][5].

Kentsin (100 μg/mL, 18 h) increases endogenous xenotropic virus expression in K-Balb 19a/h cells transformed with Kirsten sarcoma virus^[2].
Kentsin (30 μM) does not inhibit electrically stimulated contractions of the guinea pig ileum (GPI) or mouse vas deferens (MVD)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kentsin (0-100 μg, i.c.v. or intrathecal administration) produces analgesia in both the hotplate and abdominal stretch tests^[1].
Kentsin (20 and 100 ng/kg, i.c.v.) inhibits the antral motility index and disrupts the jejunal migrating motor complex in fasted dogs^[3].
Kentsin (4.0 μg/kg, i.c.v. 2 hours after the beginning of a meal) restores the “fasted” (the migrating myoelectric complex of intestinal motility), and can be blocked by previous Naloxone (400 μg/kg, i.c.v.)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

500.59

C₂₁H₄₀N₈O₆

56767-30-7

TPRK

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fox DA, et al. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8(4):613-8.  [Content Brief]

  [2]. Suk WA, et al. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. J Gen Virol. 1981 Jan;52(Pt 1):189-94.  [Content Brief]

  [3]. Bueno L, et al. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114(1):67-70.  [Content Brief]

  [4]. Buéno L, et al. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39(2):141-6.  [Content Brief]

  [5]. Wieczorek Z, et al. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15(2):215-21.  [Content Brief]