2. GPCR/G Protein
  3. Adenosine Receptor
  4. KF26777 free base

KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.

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KF26777 free base Chemical Structure

KF26777 free base Chemical Structure

CAS No. : 206129-88-6

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KF26777 free base Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
270 nM
Compound: 67, KF26777
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
Antagonist activity at human adenosine A3 receptor expressed in CHO cells by [S35]GTPgammaS binding assay
[PMID: 22468757]
Molecular Weight

374.24

Formula

C16H16BrN5O
CAS No.
SMILES

O=C1N(CCC)C2=C(NC(C3=CC=C(Br)C=C3)=N2)C4=NCCN14
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KF26777 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KF26777206129-88-6KF 26777KF-26777Adenosine ReceptorP1 receptoradenosine A3 receptorbrain ischemiainflammatory diseaseInhibitorinhibitorinhibit

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