2. Apoptosis
  3. Apoptosis
  4. Ki 23057

Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models.

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Ki 23057 Chemical Structure

Ki 23057 Chemical Structure

CAS No. : 516523-31-2

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Ki 23057 Related Antibodies

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Description

Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models[1].

Molecular Weight

501.62

Formula

C30H35N3O4
CAS No.
SMILES

COC1=C(OCCNCCO)C=C2N=CC=C(OC3=CC=C(NC4=CC=C(C(C)(C)C)C=C4)C=C3)C2=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ki 23057 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ki 23057516523-31-2Ki23057Ki-23057Apoptosisscirrhous gastric cancerOCUM-2MD3OCUM-8BALB/c nude mouseorally activeInhibitorinhibitorinhibit

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