2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. KIF18A-IN-2

KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.

For research use only. We do not sell to patients.

KIF18A-IN-2 Chemical Structure

KIF18A-IN-2 Chemical Structure

CAS No. : 2600559-20-2

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1 mg USD 230 In-stock
5 mg USD 570 In-stock
10 mg USD 800 In-stock
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50 mg USD 1800 In-stock
100 mg USD 2350 In-stock
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Based on 1 publication(s) in Google Scholar

KIF18A-IN-2 Related Antibodies

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Description

KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer[1].

IC50 & Target

IC50: 28 nM (KIF18A)[1]
Cellular Effect
Cell Line Type Value Description References
OVCAR-3 EC50
0.016 μM
Compound: 23
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
[PMID: 35286090]
OVCAR-3 EC50
0.016 μM
Compound: 23
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
[PMID: 35286090]
In Vivo

KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1]. Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice[1].

IP (100 mg/kg)
Cmax (μM) 12.6
AUC0-24 (μM·h) 147
C24h (μM) 2.9
PPB (fu) 0.007

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
Dosage: 100 mg/kg
Administration: i.p., single
Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
Molecular Weight

534.69

Formula

C25H34N4O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NS(C)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(NC(C)(C)C)(=O)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (93.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8702 mL 9.3512 mL 18.7024 mL
5 mM 0.3740 mL 1.8702 mL 3.7405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8702 mL 9.3512 mL 18.7024 mL 46.7561 mL
5 mM 0.3740 mL 1.8702 mL 3.7405 mL 9.3512 mL
10 mM 0.1870 mL 0.9351 mL 1.8702 mL 4.6756 mL
15 mM 0.1247 mL 0.6234 mL 1.2468 mL 3.1171 mL
20 mM 0.0935 mL 0.4676 mL 0.9351 mL 2.3378 mL
25 mM 0.0748 mL 0.3740 mL 0.7481 mL 1.8702 mL
30 mM 0.0623 mL 0.3117 mL 0.6234 mL 1.5585 mL
40 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1689 mL
50 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9351 mL
60 mM 0.0312 mL 0.1559 mL 0.3117 mL 0.7793 mL
80 mM 0.0234 mL 0.1169 mL 0.2338 mL 0.5845 mL
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KIF18A-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIF18A-IN-22600559-20-2Microtubule/TubulinKIF18AMicrotubuleMitoticTubulinOVCAR-3CancerInhibitorinhibitorinhibit

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