2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. KIF18A-IN-3

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer.

For research use only. We do not sell to patients.

KIF18A-IN-3 Chemical Structure

KIF18A-IN-3 Chemical Structure

CAS No. : 2600577-49-7

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Based on 1 publication(s) in Google Scholar

KIF18A-IN-3 Related Antibodies

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Description

KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].

IC50 & Target

IC50: 61 nM (KIF18A)[1]
Cellular Effect
Cell Line Type Value Description References
OVCAR-3 EC50
0.011 μM
Compound: 24
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
[PMID: 35286090]
OVCAR-3 EC50
0.011 μM
Compound: 24
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
[PMID: 35286090]
In Vivo

KIF18A-IN-3 (compound 24) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1]. Pharmacokinetic Parameters of KIF18A-IN-3 in female CD-1 mice[1].

IP (100 mg/kg)
Cmax (μM) 26.5
AUC0-24 (μM·h) 269
C24h (μM) 0.8
PPB (fu) 0.015

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
Dosage: 100 mg/kg
Administration: i.p., single
Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
Molecular Weight

574.76

Formula

C28H38N4O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NS(C2(C)CC2)(=O)=O)C=C1N3CCC4(CC4)CC3)NC5=CC=CC(S(NC(C)(C)C)(=O)=O)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7399 mL 8.6993 mL 17.3986 mL
5 mM 0.3480 mL 1.7399 mL 3.4797 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7399 mL 8.6993 mL 17.3986 mL 43.4964 mL
5 mM 0.3480 mL 1.7399 mL 3.4797 mL 8.6993 mL
10 mM 0.1740 mL 0.8699 mL 1.7399 mL 4.3496 mL
15 mM 0.1160 mL 0.5800 mL 1.1599 mL 2.8998 mL
20 mM 0.0870 mL 0.4350 mL 0.8699 mL 2.1748 mL
25 mM 0.0696 mL 0.3480 mL 0.6959 mL 1.7399 mL
30 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4499 mL
40 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0874 mL
50 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8699 mL
60 mM 0.0290 mL 0.1450 mL 0.2900 mL 0.7249 mL
80 mM 0.0217 mL 0.1087 mL 0.2175 mL 0.5437 mL
100 mM 0.0174 mL 0.0870 mL 0.1740 mL 0.4350 mL
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KIF18A-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIF18A-IN-32600577-49-7Microtubule/TubulinKIF18AMicrotubuleMitoticTubulinOVCAR-3CancerInhibitorinhibitorinhibit

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