2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. KIF18A-IN-4

KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity.

For research use only. We do not sell to patients.

KIF18A-IN-4 Chemical Structure

KIF18A-IN-4 Chemical Structure

CAS No. : 1197522-21-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

KIF18A-IN-4 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KIF18A-IN-4 is a moderately potent ATP and microtubule (MT) noncompetitive KIF18A inhibitor (IC50=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity[1].

IC50 & Target

IC50: 6.16 μM (KIF18A)[1]
Cellular Effect
Cell Line Type Value Description References
MDA-MB-157 IC50
4.8 μM
Compound: 3
Induction of mitotic arrest in TP53 mutant human MDA-MB-157 cells assessed as multipolar spindle arrays by measuring pericentriolar material incubated for 24 hrs by mitotic index assay
Induction of mitotic arrest in TP53 mutant human MDA-MB-157 cells assessed as multipolar spindle arrays by measuring pericentriolar material incubated for 24 hrs by mitotic index assay
[PMID: 35286090]
OVCAR-3 EC50
5.03 μM
Compound: 3
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
[PMID: 35286090]
OVCAR-3 EC50
6.35 μM
Compound: 3
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
[PMID: 35286090]
In Vitro

KIF18A-IN-4 (15 μM; 24 hours) induces a phenotype characterized by multipolar spindle arrays emanating from multiple pericentriolar material (PCM) centers in mitotic MDA-MB-157 cells (pH3+)[1].
KIF18A-IN-4 (0-10 μM; overnight) has an EC50 of 6.35 μM in OVCAR-3 cells by the mitotic index assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIF18A-IN-4 Related Antibodies
Molecular Weight

413.53

Formula

C22H27N3O3S
CAS No.
SMILES

O=S(C1=CC=CC(NC(C2=C(N3CCCCC3)N=CC=C2)=O)=C1)(C4CCCC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

KIF18A-IN-4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIF18A-IN-41197522-21-6Microtubule/TubulinKIF18AMicrotubuleMitoticTubulinMDA-MB-157OVCAR-3CancerInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
KIF18A-IN-4
Cat. No.:
HY-145827
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.