2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. KM-233

KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research.

For research use only. We do not sell to patients.

KM-233 Chemical Structure

KM-233 Chemical Structure

CAS No. : 628263-22-9

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Based on 1 publication(s) in Google Scholar

KM-233 Related Antibodies

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Description

KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research[1].

Cellular Effect
Cell Line Type Value Description References
LN-229 EC50
2.63 μM
Compound: 2
Cytotoxicity against human LN229 cells assessed as cell death after 18 hrs
Cytotoxicity against human LN229 cells assessed as cell death after 18 hrs
[PMID: 18524604]
T98G EC50
4.68 μM
Compound: 2
Cytotoxicity against human T98G cells assessed as cell death after 18 hrs
Cytotoxicity against human T98G cells assessed as cell death after 18 hrs
[PMID: 18524604]
U-87MG ATCC EC50
3.08 μM
Compound: 2
Cytotoxicity against human U87 cells by side flank model relative to control
Cytotoxicity against human U87 cells by side flank model relative to control
[PMID: 18524604]
Molecular Weight

362.50

Formula

C25H30O2
CAS No.
SMILES

OC1=CC(C(C2=CC=CC=C2)(C)C)=CC3=C1[C@]4([H])CC(C)=CC[C@]4(C(C)(O3)C)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KM-233 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KM-233628263-22-9KM233KM 233Cannabinoid ReceptorU87 gliomaLow toxicityBlood brain barrier penetrationHuman glioma cellsCyclical dosingInhibitorinhibitorinhibit

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