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  4. Kobusine derivative-1

Kobusine derivative-1 is a Kobusine derivative. Kobusine derivative-1 shows antiproliferative activities against cancer cells.

For research use only. We do not sell to patients.

Kobusine derivative-1 Chemical Structure

Kobusine derivative-1 Chemical Structure

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Kobusine derivative-1 Related Antibodies

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Description

Kobusine derivative-1 is a Kobusine derivative. Kobusine derivative-1 shows antiproliferative activities against cancer cells[1].

In Vitro

Kobusine derivative-1 (0-20 μM; 72 h) exhibits significant antiproliferative activities against five human cancer cell lines[1].
Kobusine derivative-1 (13.5 μM; 12 or 24 h) treatment likely induces apoptosis within 12 h, decreases numbers of cells in S and G2/M phases, resulting in accumulation of sub-G1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kobusine derivative-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A549, MDA-MB-231, MCF-7, KB, and KB-VIN cells
Concentration: 0-20 μM
Incubation Time: 72 hours
Result: Inhibited A549, MDA-MB-231, MCF-7, KB, and KB-VIN cells with IC50 values of 4.8, 4.5, 4.7, 4.6, and 4.8 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-23 cells
Concentration: 13.5 μM
Incubation Time: 12 or 24 hours
Result: Disrupted normal cell cycle progression after 12 h, decreased numbers of cells in S and G2/M phases, resulted in accumulation of sub-G1.
Molecular Weight

657.64

Formula

C36H33F6NO4
SMILES

C[C@]12[C@]3([H])[C@]4(CCC1)[C@@](N(C2)[C@H]3C5)([H])[C@@H](C[C@@H]6C7=C)[C@@]5([C@@H]7OC(C8=CC=C(C(F)(F)F)C=C8)=O)[C@@]4([H])[C@H]6OC(C9=CC=C(C(F)(F)F)C=C9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Kobusine derivative-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kobusine derivative-1Kobusine derivative1Kobusine derivative 1Othersantiproliferative activityapoptosisA549MDA-MB-231MCF-7KBKB-VINInhibitorinhibitorinhibit

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HY-149032
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