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  4. Kobusine derivative-2

Kobusine derivative-2, a kobusine derivative, has antiproliferative activity against cancer cells. Kobusine derivative-2 can induce the arrest of MDA-MB-231 cells in the sub-G1 phase. Anticancer activity.

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Kobusine derivative-2 Chemical Structure

Kobusine derivative-2 Chemical Structure

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Kobusine derivative-2 Related Antibodies

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Description

Kobusine derivative-2, a kobusine derivative, has antiproliferative activity against cancer cells. Kobusine derivative-2 can induce the arrest of MDA-MB-231 cells in the sub-G1 phase. Anticancer activity[1].

In Vitro

Kobusine derivative-2 (compound 25) (0-20 μM; 72 h) has antiproliferative activity against cancer cell lines A549, MDA-MB-231, MCF-7, KB and KB-VIN[1].
Kobusine derivative-2 (12 or 24 h; 13.3 μM) arrests MDA-MB-231 cells at the sub-G1 phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kobusine derivative-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A549, MDA-MB-231, MCF-7, KB and KB-VIN
Concentration: 0-20 μM
Incubation Time: 72 h
Result: Exhibited antiproliferative activity against cancer cell lines A549, MDA-MB-231, MCF-7, KB and KB-VIN with IC50s of 4.4 μM, 4.2 μM, 4.5 μM, 4.5 μM and 4.6 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 12 or 24 h
Incubation Time: 13.3 μM (3-fold of IC50)
Result: Decreased numbers of cells in S and G2/M phases, resulting in accumulation of sub-G1.
Molecular Weight

687.48

Formula

C36H35Cl4NO4
SMILES

C[C@]12[C@]3([H])[C@]4(CCC1)[C@@](N(C2)[C@H]3C5)([H])[C@@H](C[C@@H]6C7=C)[C@@]5([C@@H]7OC(C8=CC=C(C(Cl)Cl)C=C8)=O)[C@@]4([H])[C@H]6OC(C9=CC=C(C(Cl)Cl)C=C9)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Kobusine derivative-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kobusine derivative-2Kobusine derivative2Kobusine derivative 2OthersanticancerA549MDA-MB-231MCF-7KBKB-VINInhibitorinhibitorinhibit

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