Kocurin  (Synonyms: PM181104; Baringolin)

Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against gram-positive bacteria, but no activity against fungi and Gram-negative bacteria^[1].

Kocurin (24 h) inhibits S. aureus with MICs in the range of 0.008 to 2.048 μg/mL and an MIC₉₀ value of 0.064 μg/mL^[1].
Kocurin (24 h) inhibits S. epidermidis with MICs in the range of 0.008 to 1.024 μg/mL and an MIC₉₀ value of 0.128 μg/mL^[1].
Kocurin (24 h) inhibits VRE and VSE strains with MICs in the range of 0.004 to 1.024 μg/mL and an MIC₉₀ value of 0.016 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kocurin (1.25-10 mg/kg; intravenous injection; single dose) has the 100% effective dose (ED₁₀₀) values of 2.5 and 5.0 mg/kg for MRSA, and an ED₁₀₀ value of 10.0 mg/kg for VRE in the BALB/c mouse septicemia model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1515.70

C₆₉H₆₆N₁₈O₁₃S₅

1374772-61-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mahajan G, et al. In vitro and in vivo activities of antibiotic PM181104. Antimicrob Agents Chemother. 2013 Nov;57(11):5315-9.  [Content Brief]