2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. KOR agonist 2

KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes.

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KOR agonist 2 Chemical Structure

KOR agonist 2 Chemical Structure

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KOR agonist 2 Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes[1].

IC50 & Target

κ Opioid Receptor/KOR

1.9 nM (Ki)

Molecular Weight

543.12

Formula

C29H35ClN2O4S
SMILES

O=S(C1=CC=CC(Cl)=C1)(N(CC2=CC=CC=C2)[C@@H]3C[C@H](CN(C)C)[C@](C4=CC=CC(OC)=C4)(O)CC3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KOR agonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KOR agonist 2KOR agonist2KOR agonist-2Opioid ReceptorKunming mouseICR mouseanalgesicabdominal constriction testInhibitorinhibitorinhibit

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KOR agonist 2
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