2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12D inhibitor 25

KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 inhibits the proliferation of MIA PaCa-2 and NCI-H358 with EC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 degrades ERBB2 with a DC50 of 0.1-1 μM.

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KRAS G12D inhibitor 25 Chemical Structure

KRAS G12D inhibitor 25 Chemical Structure

CAS No. : 2768099-61-0

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KRAS G12D inhibitor 25 Related Antibodies

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Description

KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 inhibits the proliferation of MIA PaCa-2 and NCI-H358 with EC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 degrades ERBB2 with a DC50 of 0.1-1 μM[1].

Molecular Weight

1020.61

Formula

C56H62ClN11O6
CAS No.
SMILES

C=CC(N1CCN(C[C@@H]1CC#N)C2=NC(OC[C@@H]3CCCN(C3)C(C4CCN(CC4)CC5=CC=C(C=C5)N6C(O)=NN=C6C7=C(C=C(C(C(C)C)=C7)O)O)=O)=NC8=C2CCN(C8)C9=C%10C(Cl)=CC=CC%10=CC=C9)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
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KRAS G12D inhibitor 25 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12D inhibitor 252768099-61-0RasBT-474MIA PaCa-2NCI-H23NCI-H358LU65AInhibitorinhibitorinhibit

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