2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-13

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers.

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KRAS inhibitor-13 Chemical Structure

KRAS inhibitor-13 Chemical Structure

CAS No. : 2230873-96-6

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KRAS inhibitor-13 Related Antibodies

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Description

KRAS inhibitor-13 (compound 5-6) is a potent KRAS G12C inhibitor with an IC50 of 0.883 µM. KRAS inhibitor-13 shows p-ERK inhibition activities with IC50s of 5.9, >100 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-13 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

IC50 & Target[1]

KRas G12C

0.883 μM (IC50)

Molecular Weight

479.95

Formula

C25H19ClFN3O2S
CAS No.
SMILES

C=CC(N1[C@]2([H])[C@@](CC1)([H])N(C3=C4C(C(F)=C(C5=CC(O)=CC6=C5C=CC=C6)C(Cl)=C4)=NS3)C2)=O
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Purity & Documentation
References
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KRAS inhibitor-13 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-132230873-96-6KRAS inhibitor13KRAS inhibitor 13RasMIA PaCA-2A549anticancerp-ERKpancreaticcolorectallung cancerInhibitorinhibitorinhibit

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