2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS inhibitor-31

KRAS inhibitor-31 (compound 33) is a KRAS inhibitor, with KD (SPR) values of 0.019 nM, 0.019 nM and 0.096 nM for KRas G12D, KRas G12C and KRas G12V, respectively.

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KRAS inhibitor-31 Chemical Structure

KRAS inhibitor-31 Chemical Structure

CAS No. : 2920695-77-6

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KRAS inhibitor-31 Related Antibodies

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Description

KRAS inhibitor-31 (compound 33) is a KRAS inhibitor, with KD (SPR) values of 0.019 nM, 0.019 nM and 0.096 nM for KRas G12D, KRas G12C and KRas G12V, respectively[1].

IC50 & Target[1]

KRas G12D

0.019 nM (Kd)

KRas G12C

0.019 nM (Kd)

KRas G12V

0.096 nM (Kd)

In Vitro

KRAS inhibitor-31 (compound 33) exhibits IC50 values of 1.1 nM, 3.9 nM and 6.6 nM in Panc08.13, H358 and SW620 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KRAS inhibitor-31 Related Antibodies
Molecular Weight

617.62

Formula

C33H30F3N5O4
CAS No.
SMILES

FC1=C(C2=CC(O)=CC3=C2C(C#C)=C(F)C=C3)N=C4OC[C@@](COCCC5)([H])N5C6=C4C1=NC(OC[C@@]78N(CCC8)C[C@@H](C7)F)=N6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRAS inhibitor-31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS inhibitor-312920695-77-6KRAS inhibitor31KRAS inhibitor 31RasKRas G12DKRas G12CKRas G12VPanc08.13H358SW620Inhibitorinhibitorinhibit

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HY-159652
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