2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRASG12C IN-14

KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 μM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 μM.

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KRASG12C IN-14 Chemical Structure

KRASG12C IN-14 Chemical Structure

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KRASG12C IN-14 Related Antibodies

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Description

KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 μM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 μM[1].

IC50 & Target

KRas G12C

 

Molecular Weight

1088.24

Formula

C51H65F4N9O9S2
SMILES

O=C(OCC(C)(C)CC1=[C@@]([C@@]2=C([C@@H](OC)C)N=CC(N3CCOCC3)=C2)N(CC(F)(F)F)C4=C1C=C5C=C4)[C@H]6NN(C([C@@H](NC([C@H](C(C)C)N(C(N7CC(/C=C(S(C)(=O)=O)\F)C7)=O)C)=O)CC8=NC5=CS8)=O)CCC6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRASG12C IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRASG12C IN-14RasKRAS G12CERKInhibitorinhibitorinhibit

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