2. GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt
  3. Ras ERK
  4. KRASG12C IN-15

KRASG12C IN-15 (Compound 21) is the orally active inhibitor for KRASG12C, and inhibits SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. KRASG12C IN-15 inhibits the phosphorylation of ERK with IC50 of 0.051 μM. KRASG12C IN-15 inhibits the cell viability of KRASG12C mutated MIA PaCa-2 with IC50 of 0.023 μM. KRASG12C IN-15 exhibits antitumor effect in MIA PaCa-2 xenograft mouse models.

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KRASG12C IN-15 Chemical Structure

KRASG12C IN-15 Chemical Structure

CAS No. : 2768868-14-8

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KRASG12C IN-15 Related Antibodies

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Description

KRASG12C IN-15 (Compound 21) is the orally active inhibitor for KRASG12C, and inhibits SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. KRASG12C IN-15 inhibits the phosphorylation of ERK with IC50 of 0.051 μM. KRASG12C IN-15 inhibits the cell viability of KRASG12C mutated MIA PaCa-2 with IC50 of 0.023 μM. KRASG12C IN-15 exhibits antitumor effect in MIA PaCa-2 xenograft mouse models[1].

Molecular Weight

497.60

Formula

C31H32FN3O2
CAS No.
SMILES

FC1=C(N2CC3(CN(C(C=C)=O)C3)CC2)N=C([C@H](C4)C(C)(C)[C@H]4C5)C5=C1C6=CC(O)=CC7=C6C=CC=C7
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KRASG12C IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRASG12C IN-152768868-14-8RasERKExtracellular signal regulated kinasesNSCLCorally activeMIA PaCa-2Inhibitorinhibitorinhibit

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