2. Protein Tyrosine Kinase/RTK Neuronal Signaling Apoptosis Autophagy
  3. c-Met/HGFR FLT3 Trk Receptor Apoptosis Autophagy
  4. KRC-108

KRC-108, an aminopyridine, is an orally active multiple kinase inhibitor with IC50s of 80 nM, 23 nM, 3 nM, 70 nM, 30 nM, 39 nM for c-Met, c-Met M1250T, c-Met Y1230D, Ron, Flt3 and TrkA, respectively. KRC-108 induces cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 exhibits anti-tumor activity in vivo in HT29 colorectal cancer, NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice.

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KRC-108 Chemical Structure

KRC-108 Chemical Structure

CAS No. : 1146944-35-5

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KRC-108 Related Antibodies

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TrkA TrkB TrkC Trk

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Description

KRC-108, an aminopyridine, is an orally active multiple kinase inhibitor with IC50s of 80 nM, 23 nM, 3 nM, 70 nM, 30 nM, 39 nM for c-Met, c-Met M1250T, c-Met Y1230D, Ron, Flt3 and TrkA, respectively. KRC-108 induces cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 exhibits anti-tumor activity in vivo in HT29 colorectal cancer, NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice[1].

IC50 & Target[1]

c-Met

80 nM (IC50)

c-Met M1250T

23 nM (IC50)

c-Met Y1230D

3 nM (IC50)

Ron

70 nM (IC50)

Flt3

30 nM (IC50)

TrkA

39 nM (IC50)

ALK

780 nM (IC50)

VEGFR2

1660 nM (IC50)

Molecular Weight

360.41

Formula

C20H20N6O
CAS No.
SMILES

NC1=NC=C(C=C1C2=NC3=CC=CC=C3O2)C4=CN(N=C4)C5CCNCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KRC-108 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRC-1081146944-35-5KRC108KRC 108c-Met/HGFRFLT3Trk ReceptorApoptosisAutophagyCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Tropomyosin related kinase receptor aminopyridineorallyc-Met M1250Tc-Met Y1230Dcycle arrestHT29colorectal cancerNCI-H441lung cancerInhibitorinhibitorinhibit

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