2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. KRP-199

KRP-199 (compound 14h) is an α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R) antagonist (Ki=16 nM) with high potency and selectivity for AMPA-R in vitro and good neuroprotective effects in vivo. KRP-199 can be used in the study of neurodegenerative diseases.

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KRP-199 Chemical Structure

KRP-199 Chemical Structure

CAS No. : 221164-28-9

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KRP-199 Related Antibodies

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Description

KRP-199 (compound 14h) is an α-amino-3-hydroxy-5-methylisoxazolepropionic acid receptor (AMPA-R) antagonist (Ki=16 nM) with high potency and selectivity for AMPA-R in vitro and good neuroprotective effects in vivo. KRP-199 can be used in the study of neurodegenerative diseases[1].

Molecular Weight

517.37

Formula

C22H14F3N5O7
CAS No.
SMILES

O=C(C1=NC2=C(C=C(C(F)(F)F)C(N3C=C(COC(NC4=CC=C(C(O)=O)C=C4)=O)N=C3)=C2)NC1=O)O
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KRP-199 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRP-199221164-28-9KRP199KRP 199iGluRIonotropic glutamate receptorsAntagonistsNeuroprotectionNeurodegenerative DiseasesAMPA-RInhibitorinhibitorinhibit

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