2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. KT-362 free acid

KT-362 free acid is an intracellular calcium antagonist with antiarrhythmic and vasodilatory effects. KT-362 free acid shows an antagonistic effect against norepinephrine (NE) induced vasoconstriction response, achieved by reducing inositol phospholipid hydrolysis, thereby reducing intracellular calcium mobilization. KT-362 free acid can be used to study the contraction and relaxation mechanisms of vascular smooth muscle, especially in exploring the role of intracellular calcium mobilization and inositol phospholipid hydrolysis in vascular contraction.

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KT-362 free acid Chemical Structure

KT-362 free acid Chemical Structure

CAS No. : 93392-97-3

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Description

KT-362 free acid is an intracellular calcium antagonist with antiarrhythmic and vasodilatory effects. KT-362 free acid shows an antagonistic effect against norepinephrine (NE) induced vasoconstriction response, achieved by reducing inositol phospholipid hydrolysis, thereby reducing intracellular calcium mobilization. KT-362 free acid can be used to study the contraction and relaxation mechanisms of vascular smooth muscle, especially in exploring the role of intracellular calcium mobilization and inositol phospholipid hydrolysis in vascular contraction[1].

Molecular Weight

400.53

Formula

C22H28N2O3S
CAS No.
SMILES

O=C(CCNCCC1=CC=C(C(OC)=C1)OC)N2C3=C(SCCC2)C=CC=C3
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KT-362 free acid Related Classifications

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Keywords:

KT-36293392-97-3KT362KT 362Calcium ChannelCa2+ channelsCa channelsArrhythmiaVasodilationCalcium mobilizationVascular smooth muscleInhibitorinhibitorinhibit

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