2. Apoptosis
  3. Apoptosis
  4. Kusunokinin

Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis.

For research use only. We do not sell to patients.

Kusunokinin Chemical Structure

Kusunokinin Chemical Structure

CAS No. : 58311-20-9

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Kusunokinin Related Antibodies

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Description

Kusunokinin ((-)-Kusunokinin) is a nature product that could be isolated form P. nigrum. Kusunokinin has anticancer activity. Kusunokinin arrests cell cycle at G2/M phase and induce apoptosis[1].

In Vitro

Kusunokinin ((-)-Kusunokinin; 0.625-10 µg/mL; 72 h) inhibits the viability of cancer cells with IC50 values of 3.08, 3.59, 3.98, 5.75, 5.77, 7.86 µM for MCF-7, HT-29, MDA-MB-468, SW-620, A-549, MDA-MB-231 cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kusunokinin Related Antibodies

Cell Viability Assay[1]

Cell Line: Cancer cells
Concentration: 0.625, 1.25, 2.5, 5 and 10 µg/mL
Incubation Time: 72 hours
Result: Had anticancer activity and inhibited cancer cells growth.
In Vivo

Kusunokinin ((-)-Kusunokinin; 7 and 14 mg/kg; i.h.; 3 times a week for 2 weeks) attenuates tumor growth in NMU-induced breast cancer rats through the down-regulation of signaling molecules (c-Src, PI3K, Akt and Erk1/2)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague Dawley rats (7 weeks of age)[1]
Dosage: 7 and 14 mg/kg
Administration: Subcutaneous injection, 3 times a week for 2 weeks
Result: Inhibited the mammary tumor growth and decreased tumor volume.
Down-regulated c-Src, Erk1/2 and PI3K proteins and decreased Akt proteins.
Inhibited downstream molecules in the cell cycle (c-Myc, E2f-1, CDK1 and cyclin B1) and metastasis (E-cadherin, MMP-2 and MMP-9).
Molecular Weight

370.40

Formula

C21H22O6
CAS No.
SMILES

COC1=C(OC)C=C(C[C@H]2COC([C@@H]2CC3=CC4=C(OCO4)C=C3)=O)C=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Kusunokinin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kusunokinin58311-20-9(-)-KusunokininApoptosisnature productP. nigrumanticancercell cycleG2/Mcancer cellsInhibitorinhibitorinhibit

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