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  3. Disease Research Fields Plants Flavonoids Phenols
  4. Cancer other families Flavonones Polyphenols
  5. Kuwanon E

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β.

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Kuwanon E Chemical Structure

Kuwanon E Chemical Structure

CAS No. : 68401-05-8

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Kuwanon E Related Antibodies

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Description

Kuwanon E is a flavonoid isolated from Morus alba, cytotoxic to human monocytic leukemic cell lines, and reduces the level of IL-1β[1].

IC50 & Target

Kuwanon E shows cytotoxic activity against THP-1 human monocytic leukemic cell line, with an IC50 of 4.0±0.08 μM[1].
Cellular Effect
Cell Line Type Value Description References
BJ EC50
> 10 μM
Compound: 13
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
CCRF-CEM EC50
> 10 μM
Compound: 13
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
HeLa EC50
> 10 μM
Compound: 13
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
MCF7 EC50
> 10 μM
Compound: 13
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
RPMI-8226 EC50
> 10 μM
Compound: 13
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
THP-1 EC50
> 10 μM
Compound: 13
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method
[PMID: 20192247]
THP-1 IC50
4 μM
Compound: 4
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
Cytotoxicity against human THP1 cells after 24 hrs by WST1 assay
[PMID: 24901948]
U-266 EC50
> 10 μM
Compound: 13
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay
[PMID: 20192247]
Molecular Weight

424.49

Formula

C25H28O6
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(C/C=C(C)/CC/C=C(C)/C)=C(O)C=C3O)C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥96.0%

SDS (392 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References
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Kuwanon E Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kuwanon E68401-05-8OthersInhibitorinhibitorinhibit

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