Kynuramine dihydrobromide

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Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase.

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Kynuramine dihydrobromide Chemical Structure

CAS No. : 304-47-2

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Other Forms of Kynuramine dihydrobromide:

Kynuramine dihydrochloride Get quote

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Purity & Documentation
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Description

Kynuramine dihydrobromide, an endogenously occurring amine, is a fluorescent substrate of plasma amine oxidase^[1]^[2].

In Vitro

Kynuramine dihydrobromide inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro^[2].
Kynuramine dihydrobromide has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries^[2].
Kynuramine dihydrobromide (20 μg/mL) causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Kynuramine dihydrobromide (0.064-8 μg; ICV; single does) facilitates lordosis behavior in estrogen-primed ovariectomized rats^[3].
Kynuramine dihydrobromide (1.25-5.0 mg/kg; i.v.; single does) increases heart rate and blood pressure in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female rats^[3].
Dosage:	0.064, 0.32, 1.6 or 8 μg.
Administration:	Intraventricular injection; single does.
Result:	Produced facilitation of lordosis behavior.

Animal Model:	Male rats (about 200g)^[4].
Dosage:	1.25, 2.5 and 5.0 mg/kg.
Administration:	Intravenous injection; single does.
Result:	Promoted heart rate and blood pressure.

Molecular Weight

326.03

Formula

C₉H₁₄Br₂N₂O

CAS No.

304-47-2

SMILES

O=C(C1=CC=CC=C1N)CCN.[H]Br.[H]Br

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4. [Content Brief]

[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6. [Content Brief]

[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51. [Content Brief]

[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6. [Content Brief]