L-012 

L-012 is a chemiluminescent probe that reacts with various types of ROS produced by activated neutrophils in human blood, oral cavity, and rat peritoneum and produces strong chemiluminescence (CHL). L-012 produces CHL primarily by reacting with hydroxyl radicals and hypochlorite. L-012 can be used to study ROS generation in complex biological systems and the role of ROS in the pathogenesis of various diseases^[1].

288.69

C₁₃H₉ClN₄O₂

143323-55-1

O=C(C1=C2C(Cl)=NC(C3=CC=CC=C3)=C1N)NNC2=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Imada I, et al. Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012[J]. Analytical biochemistry, 1999, 271(1): 53-58.  [Content Brief]

  [2]. Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314.  [Content Brief]

  [3]. Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47(6):760-766.  [Content Brief]