L-364918

Cat. No.: HY-129333: FAQs
Data Sheet Handling Instructions

Molarity Calculator

L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with K_i values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance.

For research use only. We do not sell to patients.

L-364918 Chemical Structure

CAS No. : 122211-31-8

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Vasopressin Receptor Isoform Specific Products:

View All Isoforms

V1a Receptor V1b Receptor V2 Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

V2 Receptor

2400 nM (Ki)

V1 receptor

1300 nM (Ki)

oxytocin

30 nM (Ki)

In Vitro

L-364918 (0-1 mM) inhibits AVP-stimulated accumulation of inositol phosphates dose-dependently in hepatocytes prelabeled with inositol with an IC₅₀ value 0f 8.6 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

742.91

Formula

C₄₀H₅₄N₈O₆

CAS No.

122211-31-8

SMILES

O=C1NC(C(CC)C)C(N2NCCCC2C(N3NCCCC3C(N(C(CC4=CC=CC=C4)C(N5CCCC5C(NC1CC6=CC=CC=C6)=O)=O)C)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pettibone DJ, et al. A structurally unique, potent, and selective oxytocin antagonist derived from Streptomyces silvensis. Endocrinology. 1989 Jul;125(1):217-22. [Content Brief]

L-364918 Related Classifications

Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-364918122211-31-8L364918L 364918Oxytocin ReceptorVasopressin ReceptorOXTRarginine vasopressinpreterm laborhepatocytesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks