L 657925

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Data Sheet Handling Instructions

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L 657925 is a potent thromboxane A2 (TXA2) antagonist. L 657925 selectively abolishes ONO 11113-evoked transient increment in [Ca2²⁺].

For research use only. We do not sell to patients.

L 657925 Chemical Structure

CAS No. : 122757-59-9

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DP EP FP IP TXA₂/TP TXB₂

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Purity & Documentation
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Description

L 657925 is a potent thromboxane A2 (TXA2) antagonist. L 657925 selectively abolishes ONO 11113-evoked transient increment in [Ca2²⁺]^[1].

IC₅₀ & Target^[1]

TXA₂

Molecular Weight

373.85

Formula

C₂₁H₂₁ClFNO₂

CAS No.

122757-59-9

SMILES

FC1=CC=C(N(C2([H])C3([H])CCCC2CC(O)=O)CC4=CC=C(C=C4)Cl)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ueda N, et al. Receptor-mediated increase in cytosolic calcium in LLC-PK1 cells by platelet activating factor and thromboxane A2. Kidney Int. 1991 Dec;40(6):1075-81. [Content Brief]

L 657925 Related Classifications

Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L 657925122757-59-9L657925L-657925Prostaglandin ReceptorCa2+ONO 11113Inhibitorinhibitorinhibit

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