2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. L-706000 free base

L-706000 free base  (Synonyms: MK 499 free base)

Cat. No.: HY-106912A
Handling Instructions

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L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias.

For research use only. We do not sell to patients.

L-706000 free base Chemical Structure

L-706000 free base Chemical Structure

CAS No. : 161799-18-4

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L-706000 free base Related Antibodies

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Description

L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias[1].

IC50 & Target

IC50: 32 nM (hERG channel)[1]
Molecular Weight

467.58

Formula

C25H29N3O4S
CAS No.
SMILES

O[C@@H]1CC2(CCN([C@@](CCC3=C4)([H])CC3=CC=C4C#N)CC2)OC(C1=C5)=CC=C5N[S](C)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-706000 free base Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-706000161799-18-4MK 499L706000L 706000MK499MK-499Potassium ChannelKcsAhERG channel blockerantiarrhythmic agentmalignant ventricular tachyarrhythmiasInhibitorinhibitorinhibit

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