L-706000 free base (Synonyms: MK 499 free base)

Cat. No.: HY-106912A: FAQs
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L-706000 (MK 499) free base is a potent hERG channel blocker with an IC₅₀ of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias.

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L-706000 free base Chemical Structure

CAS No. : 161799-18-4

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Description	L-706000 (MK 499) free base is a potent hERG channel blocker with an IC₅₀ of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias^[1].
IC₅₀ & Target	IC50: 32 nM (hERG channel)^[1]
Molecular Weight	467.58
Formula	C₂₅H₂₉N₃O₄S
CAS No.	161799-18-4
SMILES	O[C@@H]1CC2(CCN([C@@](CCC3=C4)([H])CC3=CC=C4C#N)CC2)OC(C1=C5)=CC=C5N[S](C)(=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. J S Mitcheson, et al. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000 Mar;115(3):229-40. [Content Brief] [2]. S Vickers, et al. Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs. Drug Metab Dispos. 1998 May;26(5):388-95. [Content Brief]

L-706000 free base Related Classifications

Cardiovascular Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-706000161799-18-4MK 499L706000L 706000MK499MK-499Potassium ChannelKcsAhERG channel blockerantiarrhythmic agentmalignant ventricular tachyarrhythmiasInhibitorinhibitorinhibit

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L-706000 free base (Synonyms: MK 499 free base)

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