2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. L-736380

L-736380 is a high affinity CCK-B (cholecystokinin B receptor) receptor antagonist, with IC50 values of 0.054 nM and 400 nM for CCK-B and CCK-A, respectively. L-736380 dose-dependently inhibits gastric acid secretion in anesthetized rats (ID50, 0.064 mg/kg) and ex vivo binding of [125I]CCK-8S in BKTO mice brain membranes (ED50, 1.7 mg/kg).

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L-736380 Chemical Structure

L-736380 Chemical Structure

CAS No. : 152885-49-9

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Description

L-736380 is a high affinity CCK-B (cholecystokinin B receptor) receptor antagonist, with IC50 values of 0.054 nM and 400 nM for CCK-B and CCK-A, respectively. L-736380 dose-dependently inhibits gastric acid secretion in anesthetized rats (ID50, 0.064 mg/kg) and ex vivo binding of [125I]CCK-8S in BKTO mice brain membranes (ED50, 1.7 mg/kg)[1].

Molecular Weight

487.56

Formula

C25H29N9O2
CAS No.
SMILES

O=C(N[C@H]1C(N(C2=CC=CC=C2C(C3CCCCC3)=N1)C)=O)NC4=CC=CC(N(C5=NNN=N5)C)=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-736380 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-736380152885-49-9L736380L 736380Cholecystokinin ReceptorCCK ReceptorCCK-BCCK-A,Inhibitorinhibitorinhibit

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