2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. L-902688

L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors.

For research use only. We do not sell to patients.

L-902688 Chemical Structure

L-902688 Chemical Structure

CAS No. : 634193-54-7

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Solvent
1 mg (11.92 mM * 200 μL in Methanol) USD 460 In-stock
Solvent
5 mg (11.92 mM * 1 mL in Methanol) USD 1610 In-stock
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Based on 2 publication(s) in Google Scholar

L-902688 Related Antibodies

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Description

L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2].

IC50 & Target[2]

EP4

0.38 nM (Ki)

EP4

0.6 nM (EC50)

In Vitro

L-902688 (1 µM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-902688 Related Antibodies

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 1 µM
Incubation Time: 24 hours
Result: Attenuated TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression.
In Vivo

L-902688 (0.25-1 µg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats injected with crotaline to induce pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy[1]
Dosage: 0.25 µg/kg/day, 0.4 µg/kg/day or 1 µg/kg/day
Administration: Intraperitoneal injection; daily; for 3 weeks
Result: Reduced right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model.
Molecular Weight

419.47

Formula

C21H27F2N5O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O[C@@]([H])(C(F)(C1=CC=CC=C1)F)/C=C/[C@@H](CCC2=O)N2CCCCCCC3=NN=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

COA (255 KB)

Handling Instructions (2659 KB)
References
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L-902688 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-902688634193-54-7L902688L 902688Prostaglandin ReceptorEP4α-SMAcardiacfibrosisTwistTGF-βendothelial-mesenchymaltransitionInhibitorinhibitorinhibit

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