L-AP6

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L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.

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L-AP6 Chemical Structure

CAS No. : 78944-89-5

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Description

L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Pyramidal neuron	IC₅₀	0.17 μM Compound: L-AP6	sensitization of CA1 pyramidal neurons to depolarizations by L-AP6 after exposure to quisqualic acid sensitization of CA1 pyramidal neurons to depolarizations by L-AP6 after exposure to quisqualic acid	[PMID: 7966155]
Pyramidal neuron	IC₅₀	11 μM Compound: L-AP6	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 before exposure to quisqualic acid	[PMID: 7966155]
Pyramidal neuron	IC₅₀	12 μM Compound: L-AP6	sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA sensitization of CA1 pyramidal neurons by 2 to depolarizations by L-AP4, L-AP5 and L-AP6 after reversal with L-alpha-AA	[PMID: 7966155]

Molecular Weight

211.15

Formula

C₆H₁₄NO₅P

CAS No.

78944-89-5

SMILES

NC(CCCCP(O)(O)=O)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schulte MK, et, al. Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 Jun 27;649(1-2):203-7. [Content Brief]

L-AP6 Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-AP678944-89-5OthersInhibitorinhibitorinhibit

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