L-Arginine-¹⁵N₄ hydrochloride (Synonyms: (S)-(+)-Arginine-¹⁵N₄ hydrochloride)

Name: L-Arginine- 15 N 4 hydrochloride
Brand: MedChemExpress
SKU: HY-N0455AS1
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0455AS1 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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L-Arginine-¹⁵N₄ (hydrochloride) is the ¹⁵N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].

For research use only. We do not sell to patients.

L-Arginine-<sup>15</sup>N<sub>4</sub> hydrochloride Chemical Structure

L-Arginine-¹⁵N₄ hydrochloride Chemical Structure

CAS No. : 204633-95-4

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
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100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Arginine-¹⁵N₄ hydrochloride:

L-Arginine hydrochloride In-stock
L-Arginine-¹³C₆,d₁₄ hydrochloride Get quote

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

214.64

Formula

C₆H₁₅Cl¹⁵N₄O₂

CAS No.

204633-95-4

Unlabeled CAS

1119-34-2

Appearance

Solid

Color

White to off-white

SMILES

[15NH]=C([15NH2])[15NH]CCC[C@H]([15NH2])C(O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1164.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6590 mL	23.2948 mL	46.5896 mL
5 mM	0.9318 mL	4.6590 mL	9.3179 mL
10 mM	0.4659 mL	2.3295 mL	4.6590 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (281 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [Content Brief]

[3]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [Content Brief]

[4]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.6590 mL	23.2948 mL	46.5896 mL	116.4741 mL
	5 mM	0.9318 mL	4.6590 mL	9.3179 mL	23.2948 mL
	10 mM	0.4659 mL	2.3295 mL	4.6590 mL	11.6474 mL
	15 mM	0.3106 mL	1.5530 mL	3.1060 mL	7.7649 mL
	20 mM	0.2329 mL	1.1647 mL	2.3295 mL	5.8237 mL
	25 mM	0.1864 mL	0.9318 mL	1.8636 mL	4.6590 mL
	30 mM	0.1553 mL	0.7765 mL	1.5530 mL	3.8825 mL
	40 mM	0.1165 mL	0.5824 mL	1.1647 mL	2.9119 mL
	50 mM	0.0932 mL	0.4659 mL	0.9318 mL	2.3295 mL
	60 mM	0.0776 mL	0.3882 mL	0.7765 mL	1.9412 mL
	80 mM	0.0582 mL	0.2912 mL	0.5824 mL	1.4559 mL
	100 mM	0.0466 mL	0.2329 mL	0.4659 mL	1.1647 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Arginine-¹⁵N₄ hydrochloride Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Arginine-¹⁵N₄204633-95-4(S)-(+)-Arginine-¹⁵N₄Isotope-Labeled CompoundsNO SynthaseEndogenous MetaboliteNitric oxide synthasesNOSInhibitorinhibitorinhibit

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L-Arginine-15N4 hydrochloride (Synonyms: (S)-(+)-Arginine-15N4 hydrochloride)

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References

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L-Arginine-15N4 hydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

L-Arginine-15N4 hydrochloride Related Classifications

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L-Arginine-¹⁵N₄ hydrochloride (Synonyms: (S)-(+)-Arginine-¹⁵N₄ hydrochloride)

Other Forms of L-Arginine-¹⁵N₄ hydrochloride:

L-Arginine-¹⁵N₄ hydrochloride Related Antibodies

L-Arginine-¹⁵N₄ hydrochloride Related Antibodies

L-Arginine-¹⁵N₄ hydrochloride Related Classifications