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L-Arginine butanoate  (Synonyms: (S)-(+)-Arginine butanoate)

Cat. No.: HY-N0455D Purity: ≥98.0%
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L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations.

For research use only. We do not sell to patients.

L-Arginine butanoate Chemical Structure

L-Arginine butanoate Chemical Structure

CAS No. : 80407-72-3

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Based on 9 publication(s) in Google Scholar

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Description

L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations[1].

In Vivo

Induction of experimental acute pancreatitis[4][5]

Background
L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS) to produce NO, which can be metabolized into nitric oxide (NO), polyamines or L-proline, stimulating inflammatory responses. L-Arginine can also selectively destroy pancreatic acinar cells, leading to acute necrotizing pancreatitis.
Specific Mmodeling Methods
Rat[4]: male • Wistar albino rats • 150 g
Administration: 250 mg, 500 mg, 750 mg every 100 g body weight (L-Arginine for example; HY-N0455) • ip for single dose • starved for 15 hours
Mice[5]: male • ICT mouse • 4-week-old • 25-30 g
Administration: total 450 mg/100 g body weight • ip for 2 doses, with 1 hr interval • sacrificed at 72 hours
Note
1. 当剂量超过 500 mg/100 g 体重时，将导致大部分大鼠在注射后数小时内死亡；当接受剂量低于 250 mg 时，诱导出现的胰腺病的症状会较轻[4]。
2. 文献中溶解方法参考[5]：将 L-Arginine 粉末溶解于 0.9% 生理盐水中，用 5 N 盐酸调节 pH 至 7，制得 L-Arginine 溶液。
Modeling Record
Appearance changes: weight loss, lower activity, softer hair
Tissue morphology: pancreatic edema, damage, atrophy, granulation tissue contraction and chalky spots (location of fat necrosis).
Cellular changes: basophils decrease and vesicles, cell pyknosis, nuclear fragmentation. Pancreatic albino cells disappear and die, and pancreatic tissue is replaced by monocytes and fibroblasts.
Molecular changes: serum amylase levels increase, and fat necrosis is obvious.
Correlated Product(s): Curcumin (HY-N0005)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

291.67

Formula

C6H14N4O2.4/3C4H8O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)NCCC[C@H](N)C(O)=O.OC(CCC)=O.[4/3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (342.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4285 mL 17.1427 mL 34.2853 mL
5 mM 0.6857 mL 3.4285 mL 6.8571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.4285 mL 17.1427 mL 34.2853 mL 85.7133 mL
5 mM 0.6857 mL 3.4285 mL 6.8571 mL 17.1427 mL
10 mM 0.3429 mL 1.7143 mL 3.4285 mL 8.5713 mL
15 mM 0.2286 mL 1.1428 mL 2.2857 mL 5.7142 mL
20 mM 0.1714 mL 0.8571 mL 1.7143 mL 4.2857 mL
25 mM 0.1371 mL 0.6857 mL 1.3714 mL 3.4285 mL
30 mM 0.1143 mL 0.5714 mL 1.1428 mL 2.8571 mL
40 mM 0.0857 mL 0.4286 mL 0.8571 mL 2.1428 mL
50 mM 0.0686 mL 0.3429 mL 0.6857 mL 1.7143 mL
60 mM 0.0571 mL 0.2857 mL 0.5714 mL 1.4286 mL
80 mM 0.0429 mL 0.2143 mL 0.4286 mL 1.0714 mL
100 mM 0.0343 mL 0.1714 mL 0.3429 mL 0.8571 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Arginine butanoate80407-72-3(S)-(+)-Arginine butanoateOthersnutrientsshort-chain fatty acidfood additiveInhibitorinhibitorinhibit

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