L-Arginine-N-FMOC PBF-OH-¹³C₆ 

L-Arginine-N-FMOC PBF-OH-¹³C₆ is the ¹³C labeled Fmoc-Arg(Pbf)-OH[1]. Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis)[2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

654.72

C₂₈¹³C₆H₄₀N₄O₇S

O=S(N[13C](N[13CH2][13CH2][13CH2][13C@@H]([13C](O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=N)(C4=C(C)C(C)=C5OC(C)(C)CC5=C4C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Beatriz G, et al. Successful development of a method for the incorporation of Fmoc-Arg (Pbf)-OH in solid-phase peptide synthesis using N-butylpyrrolidinone (NBP) as solvent. Green Chemistry, 2020, 22(10): 3162-3169.