L-Aspartic acid-¹³C

Name: L-Aspartic acid- 13 C
Brand: MedChemExpress
SKU: HY-N0666S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0666S Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Aspartic acid-¹³C is a ¹³C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[1][2].

For research use only. We do not sell to patients.

L-Aspartic acid-<sup>13</sup>C Chemical Structure

L-Aspartic acid-¹³C Chemical Structure

CAS No. : 81201-97-0

Size	Price	Stock	Quantity
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 530	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Aspartic acid-¹³C:

L-Aspartic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Aspartic acid-¹³C is a ¹³C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly[1][2].

In Vitro

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly^[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

134.10

Formula

C₃¹³CH₇NO₄

CAS No.

81201-97-0

Unlabeled CAS

56-84-8

Appearance

Solid

Color

White to off-white

SMILES

OC(C[C@H](N)[13C](O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (149.14 mM; ultrasonic and adjust pH to 3 with 1 M HCL)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4571 mL	37.2856 mL	74.5712 mL
5 mM	1.4914 mL	7.4571 mL	14.9142 mL
10 mM	0.7457 mL	3.7286 mL	7.4571 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (14.91 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (419 KB)

COA (247 KB) HNMR (243 KB)

Handling Instructions (2659 KB)

References

[1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406. [Content Brief]

[2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.4571 mL	37.2856 mL	74.5712 mL	186.4280 mL
	5 mM	1.4914 mL	7.4571 mL	14.9142 mL	37.2856 mL
	10 mM	0.7457 mL	3.7286 mL	7.4571 mL	18.6428 mL
	15 mM	0.4971 mL	2.4857 mL	4.9714 mL	12.4285 mL
	20 mM	0.3729 mL	1.8643 mL	3.7286 mL	9.3214 mL
	25 mM	0.2983 mL	1.4914 mL	2.9828 mL	7.4571 mL
	30 mM	0.2486 mL	1.2429 mL	2.4857 mL	6.2143 mL
	40 mM	0.1864 mL	0.9321 mL	1.8643 mL	4.6607 mL
	50 mM	0.1491 mL	0.7457 mL	1.4914 mL	3.7286 mL
	60 mM	0.1243 mL	0.6214 mL	1.2429 mL	3.1071 mL
	80 mM	0.0932 mL	0.4661 mL	0.9321 mL	2.3304 mL
	100 mM	0.0746 mL	0.3729 mL	0.7457 mL	1.8643 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.