L-Aspartic acid-¹³C₄

Name: L-Aspartic acid- 13 C 4
Brand: MedChemExpress
SKU: HY-N0666S4
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0666S4 Purity: 98.30%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

L-Aspartic acid-¹³C₄ is the ¹³C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

For research use only. We do not sell to patients.

L-Aspartic acid-<sup>13</sup>C<sub>4</sub> Chemical Structure

L-Aspartic acid-¹³C₄ Chemical Structure

CAS No. : 55443-54-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Aspartic acid-¹³C₄:

L-Aspartic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Aspartic acid-¹³C₄ is the ¹³C-labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	15 μM Compound: 5960	Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells	10.5281/zenodo.6782621
HEK293	EC₅₀	398 μM Compound: L-asp	Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells	[PMID: 35677430]

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

137.07

Formula

¹³C₄H₇NO₄

CAS No.

55443-54-4

Unlabeled CAS

56-84-8

Appearance

Solid

Color

White to off-white

SMILES

O[13C]([13C@](N)([H])[13C]([H])([H])[13C](O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

1 M NaOH : 100 mg/mL (729.55 mM; adjust pH to 12 with 1 M NaOH)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.2955 mL	36.4777 mL	72.9554 mL
5 mM	1.4591 mL	7.2955 mL	14.5911 mL
10 mM	0.7296 mL	3.6478 mL	7.2955 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.30%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

1 M NaOH	1 mM	7.2955 mL	36.4777 mL	72.9554 mL	182.3886 mL
	5 mM	1.4591 mL	7.2955 mL	14.5911 mL	36.4777 mL
	10 mM	0.7296 mL	3.6478 mL	7.2955 mL	18.2389 mL
	15 mM	0.4864 mL	2.4318 mL	4.8637 mL	12.1592 mL
	20 mM	0.3648 mL	1.8239 mL	3.6478 mL	9.1194 mL
	25 mM	0.2918 mL	1.4591 mL	2.9182 mL	7.2955 mL
	30 mM	0.2432 mL	1.2159 mL	2.4318 mL	6.0796 mL
	40 mM	0.1824 mL	0.9119 mL	1.8239 mL	4.5597 mL
	50 mM	0.1459 mL	0.7296 mL	1.4591 mL	3.6478 mL
	60 mM	0.1216 mL	0.6080 mL	1.2159 mL	3.0398 mL
	80 mM	0.0912 mL	0.4560 mL	0.9119 mL	2.2799 mL
	100 mM	0.0730 mL	0.3648 mL	0.7296 mL	1.8239 mL