L-Azidohomoalanine hydrochloride

Name: L-Azidohomoalanine hydrochloride
Brand: MedChemExpress
SKU: HY-140346A
Rating: 5.0 (4 reviews)

Cat. No.: HY-140346A Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

L-Azidohomoalanine hydrochloride Chemical Structure

CAS No. : 942518-29-8

Size	Price	Stock	Quantity
50 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of L-Azidohomoalanine hydrochloride:

L-Azidohomoalanine-1,2,3,4-¹³C₄ hydrochloride Get quote
L-Azidohomoalanine Get quote

4 Publications Citing Use of MCE L-Azidohomoalanine hydrochloride

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Biological Activity
Purity & Documentation
References
Customer Review

Description

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

180.59

Formula

C₄H₉ClN₄O₂

CAS No.

942518-29-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCN=[N+]=[N-].[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (553.74 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5374 mL	27.6870 mL	55.3741 mL
5 mM	1.1075 mL	5.5374 mL	11.0748 mL
10 mM	0.5537 mL	2.7687 mL	5.5374 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (553.74 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (245 KB) HNMR (275 KB) LCMS (259 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.5374 mL	27.6870 mL	55.3741 mL	138.4351 mL
	5 mM	1.1075 mL	5.5374 mL	11.0748 mL	27.6870 mL
	10 mM	0.5537 mL	2.7687 mL	5.5374 mL	13.8435 mL
	15 mM	0.3692 mL	1.8458 mL	3.6916 mL	9.2290 mL
	20 mM	0.2769 mL	1.3844 mL	2.7687 mL	6.9218 mL
	25 mM	0.2215 mL	1.1075 mL	2.2150 mL	5.5374 mL
	30 mM	0.1846 mL	0.9229 mL	1.8458 mL	4.6145 mL
	40 mM	0.1384 mL	0.6922 mL	1.3844 mL	3.4609 mL
	50 mM	0.1107 mL	0.5537 mL	1.1075 mL	2.7687 mL
	60 mM	0.0923 mL	0.4615 mL	0.9229 mL	2.3073 mL
	80 mM	0.0692 mL	0.3461 mL	0.6922 mL	1.7304 mL
	100 mM	0.0554 mL	0.2769 mL	0.5537 mL	1.3844 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.