2. PROTAC
  3. PROTAC Linkers
  4. L-Azidohomoalanine hydrochloride

L-Azidohomoalanine hydrochloride 

Cat. No.: HY-140346A Purity: 99.76%
COA Handling Instructions

Molarity Calculator

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

L-Azidohomoalanine hydrochloride Chemical Structure

L-Azidohomoalanine hydrochloride Chemical Structure

CAS No. : 942518-29-8

Size Price Stock Quantity
50 mg USD 110 In-stock
100 mg USD 140 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 4 publication(s) in Google Scholar

Other Forms of L-Azidohomoalanine hydrochloride:

L-Azidohomoalanine hydrochloride Related Antibodies

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Description

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Alkyl-Chain

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Azidohomoalanine hydrochloride Related Antibodies
Molecular Weight

180.59

Formula

C4H9ClN4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCN=[N+]=[N-].[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (692.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5374 mL 27.6870 mL 55.3741 mL
5 mM 1.1075 mL 5.5374 mL 11.0748 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (553.74 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.76%

COA (245 KB) HNMR (275 KB) LCMS (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5374 mL 27.6870 mL 55.3741 mL 138.4351 mL
5 mM 1.1075 mL 5.5374 mL 11.0748 mL 27.6870 mL
10 mM 0.5537 mL 2.7687 mL 5.5374 mL 13.8435 mL
15 mM 0.3692 mL 1.8458 mL 3.6916 mL 9.2290 mL
20 mM 0.2769 mL 1.3844 mL 2.7687 mL 6.9218 mL
25 mM 0.2215 mL 1.1075 mL 2.2150 mL 5.5374 mL
30 mM 0.1846 mL 0.9229 mL 1.8458 mL 4.6145 mL
40 mM 0.1384 mL 0.6922 mL 1.3844 mL 3.4609 mL
50 mM 0.1107 mL 0.5537 mL 1.1075 mL 2.7687 mL
60 mM 0.0923 mL 0.4615 mL 0.9229 mL 2.3073 mL
80 mM 0.0692 mL 0.3461 mL 0.6922 mL 1.7304 mL
100 mM 0.0554 mL 0.2769 mL 0.5537 mL 1.3844 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Azidohomoalanine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Azidohomoalanine942518-29-8PROTAC LinkersInhibitorinhibitorinhibit

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