2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Endogenous Metabolite iGluR Ferroptosis Apoptosis
  4. L-Glutamic acid-d3

L-Glutamic acid-d3 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

For research use only. We do not sell to patients.

L-Glutamic acid-d<sub>3</sub> Chemical Structure

L-Glutamic acid-d3 Chemical Structure

CAS No. : 203805-84-9

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Glutamic acid-d3:

L-Glutamic acid-d3 Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

L-Glutamic acid-d3 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Glutamic acid-d3 Related Antibodies
Molecular Weight

150.15

Formula

C5H6D3NO4
CAS No.
Unlabeled CAS

56-86-0
Appearance

Solid

Color

White to off-white

SMILES

OC(C([2H])([2H])C[C@@](N)([2H])C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (66.60 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6600 mL 33.3000 mL 66.6001 mL
5 mM 1.3320 mL 6.6600 mL 13.3200 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.00%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.6600 mL 33.3000 mL 66.6001 mL 166.5002 mL
5 mM 1.3320 mL 6.6600 mL 13.3200 mL 33.3000 mL
10 mM 0.6660 mL 3.3300 mL 6.6600 mL 16.6500 mL
15 mM 0.4440 mL 2.2200 mL 4.4400 mL 11.1000 mL
20 mM 0.3330 mL 1.6650 mL 3.3300 mL 8.3250 mL
25 mM 0.2664 mL 1.3320 mL 2.6640 mL 6.6600 mL
30 mM 0.2220 mL 1.1100 mL 2.2200 mL 5.5500 mL
40 mM 0.1665 mL 0.8325 mL 1.6650 mL 4.1625 mL
50 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3300 mL
60 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Glutamic acid-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutamic acid-d3203805-84-9Endogenous MetaboliteiGluRFerroptosisApoptosisIonotropic glutamate receptorsInhibitorinhibitorinhibit

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