L-Glutamic acid-d₃

Name: L-Glutamic acid-d 3
Brand: MedChemExpress
SKU: HY-14608S8
Rating: 4.5 (1 reviews)

Cat. No.: HY-14608S8 Purity: 98.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Glutamic acid-d₃ is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

For research use only. We do not sell to patients.

L-Glutamic acid-d<sub>3</sub> Chemical Structure

L-Glutamic acid-d₃ Chemical Structure

CAS No. : 203805-84-9

Size	Price	Stock	Quantity
1 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Glutamic acid-d₃:

L-Glutamic acid In-stock

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AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

150.15

Formula

C₅H₆D₃NO₄

CAS No.

203805-84-9

Unlabeled CAS

56-86-0

Appearance

Solid

Color

White to off-white

SMILES

OC(C([2H])([2H])C[C@@](N)([2H])C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 10 mg/mL (66.60 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6600 mL	33.3000 mL	66.6001 mL
5 mM	1.3320 mL	6.6600 mL	13.3200 mL
10 mM	0.6660 mL	3.3300 mL	6.6600 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.6600 mL	33.3000 mL	66.6001 mL	166.5002 mL
	5 mM	1.3320 mL	6.6600 mL	13.3200 mL	33.3000 mL
	10 mM	0.6660 mL	3.3300 mL	6.6600 mL	16.6500 mL
	15 mM	0.4440 mL	2.2200 mL	4.4400 mL	11.1000 mL
	20 mM	0.3330 mL	1.6650 mL	3.3300 mL	8.3250 mL
	25 mM	0.2664 mL	1.3320 mL	2.6640 mL	6.6600 mL
	30 mM	0.2220 mL	1.1100 mL	2.2200 mL	5.5500 mL
	40 mM	0.1665 mL	0.8325 mL	1.6650 mL	4.1625 mL
	50 mM	0.1332 mL	0.6660 mL	1.3320 mL	3.3300 mL
	60 mM	0.1110 mL	0.5550 mL	1.1100 mL	2.7750 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.