L-Hydroxyproline-d₃

Name: L-Hydroxyproline-d 3
Brand: MedChemExpress
SKU: HY-40135S
Rating: 4.5 (1 reviews)

Cat. No.: HY-40135S Purity: 98.67%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Hydroxyproline-d₃ is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

For research use only. We do not sell to patients.

L-Hydroxyproline-d<sub>3</sub> Chemical Structure

L-Hydroxyproline-d₃ Chemical Structure

CAS No. : 1356016-86-8

Size	Price	Stock	Quantity
1 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1320	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Hydroxyproline-d₃:

L-Hydroxyproline In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

134.15

Formula

C₅H₆D₃NO₃

CAS No.

1356016-86-8

Unlabeled CAS

51-35-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@](C1)([2H])NC([2H])([2H])[C@@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (372.72 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.4543 mL	37.2717 mL	74.5434 mL
5 mM	1.4909 mL	7.4543 mL	14.9087 mL
10 mM	0.7454 mL	3.7272 mL	7.4543 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.67%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (256 KB) HNMR (772 KB) RP-HPLC (791 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.4543 mL	37.2717 mL	74.5434 mL	186.3586 mL
	5 mM	1.4909 mL	7.4543 mL	14.9087 mL	37.2717 mL
	10 mM	0.7454 mL	3.7272 mL	7.4543 mL	18.6359 mL
	15 mM	0.4970 mL	2.4848 mL	4.9696 mL	12.4239 mL
	20 mM	0.3727 mL	1.8636 mL	3.7272 mL	9.3179 mL
	25 mM	0.2982 mL	1.4909 mL	2.9817 mL	7.4543 mL
	30 mM	0.2485 mL	1.2424 mL	2.4848 mL	6.2120 mL
	40 mM	0.1864 mL	0.9318 mL	1.8636 mL	4.6590 mL
	50 mM	0.1491 mL	0.7454 mL	1.4909 mL	3.7272 mL
	60 mM	0.1242 mL	0.6212 mL	1.2424 mL	3.1060 mL
	80 mM	0.0932 mL	0.4659 mL	0.9318 mL	2.3295 mL
	100 mM	0.0745 mL	0.3727 mL	0.7454 mL	1.8636 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.