2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. L-Hyoscyamine-d3

L-Hyoscyamine-d3  (Synonyms: Daturine-d3)

Cat. No.: HY-N0471S Purity: 98.87%
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L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].

For research use only. We do not sell to patients.

L-Hyoscyamine-d<sub>3</sub> Chemical Structure

L-Hyoscyamine-d3 Chemical Structure

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1 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of L-Hyoscyamine-d3:

L-Hyoscyamine-d3 Related Antibodies

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

L-Hyoscyamine-d3 is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205)[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Hyoscyamine-d3 Related Antibodies
Molecular Weight

292.39

Formula

C17H20D3NO3
Unlabeled CAS

101-31-5
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](C1=CC=CC=C1)CO)O[C@H]2C[C@H]3CC[C@H](N3C([2H])([2H])[2H])C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (342.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4201 mL 17.1004 mL 34.2009 mL
5 mM 0.6840 mL 3.4201 mL 6.8402 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.4201 mL 17.1004 mL 34.2009 mL 85.5022 mL
5 mM 0.6840 mL 3.4201 mL 6.8402 mL 17.1004 mL
10 mM 0.3420 mL 1.7100 mL 3.4201 mL 8.5502 mL
15 mM 0.2280 mL 1.1400 mL 2.2801 mL 5.7001 mL
20 mM 0.1710 mL 0.8550 mL 1.7100 mL 4.2751 mL
25 mM 0.1368 mL 0.6840 mL 1.3680 mL 3.4201 mL
30 mM 0.1140 mL 0.5700 mL 1.1400 mL 2.8501 mL
40 mM 0.0855 mL 0.4275 mL 0.8550 mL 2.1376 mL
50 mM 0.0684 mL 0.3420 mL 0.6840 mL 1.7100 mL
60 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4250 mL
80 mM 0.0428 mL 0.2138 mL 0.4275 mL 1.0688 mL
100 mM 0.0342 mL 0.1710 mL 0.3420 mL 0.8550 mL
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L-Hyoscyamine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Hyoscyamine-d3Daturine-d3mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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