2. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. mTOR Endogenous Metabolite
  4. L-Leucine-1-13C,15N

L-Leucine-1-13C,15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

For research use only. We do not sell to patients.

L-Leucine-1-<sup>13</sup>C,<sup>15</sup>N Chemical Structure

L-Leucine-1-13C,15N Chemical Structure

CAS No. : 80134-83-4

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Leucine-1-13C,15N:

L-Leucine-1-13C,15N Related Antibodies

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Description

L-Leucine-1-13C,15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Leucine-1-13C,15N Related Antibodies
Molecular Weight

133.16

Formula

C513CH1315NO2
CAS No.
Unlabeled CAS

61-90-5
Appearance

Solid

Color

White to off-white

SMILES

[15NH2][C@@H](CC(C)C)[13C](O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

PBS (pH 7.2) : ≥ 1 mg/mL (7.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5098 mL 37.5488 mL 75.0976 mL
5 mM 1.5020 mL 7.5098 mL 15.0195 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) 1 mM 7.5098 mL 37.5488 mL 75.0976 mL 187.7441 mL
5 mM 1.5020 mL 7.5098 mL 15.0195 mL 37.5488 mL
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L-Leucine-1-13C,15N Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Leucine-1-13C,15N80134-83-4mTOREndogenous MetaboliteMammalian target of RapamycinInhibitorinhibitorinhibit

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